BitcoinWorld US AI Startups Secure Astonishing $100M+ Funding Rounds in 2025 For those tracking the pulse of technological advancement and investment opportunities, the surge in artificial intelligence (AI) funding continues to be a dominant theme. While the crypto world often focuses on decentralized innovations, understanding broader tech trends, particularly in areas like AI that increasingly intersect with blockchain applications, is crucial. The year 2025 is already demonstrating a robust continuation of the momentum seen in 2024, with US AI startups attracting significant capital, including numerous rounds exceeding the remarkable $100 million threshold. This influx of Venture Capital underscores the perceived potential and rapid development within the Artificial Intelligence sector. The Continued Surge in AI Funding Last year set a high bar for AI investment, with many companies securing substantial funding. The question was whether 2025 could maintain this pace. Early indications suggest it can. The first half of 2025 has already seen multiple billion-dollar funding rounds, and the number of AI megarounds ($100M or more) closed in the US during Q1 2025 surpassed that of Q1 2024. This trend highlights the increasing maturity and investor confidence in various AI applications and infrastructure. This significant AI funding is distributed across diverse areas, from foundational AI research and model development to specialized applications in enterprise software, healthcare, legal tech, and even defense. Investors are betting on AI’s potential to revolutionize industries and create massive new markets. Let’s take a closer look at the US AI startups that have successfully raised $100 million or more so far this year. Which US AI Startups Secured Major AI Investment in 2025? Here is a breakdown of the US-based Artificial Intelligence companies that have announced funding rounds of $100 million or greater in 2025, offering a snapshot of where significant Venture Capital is flowing within the AI landscape: June Glean: An enterprise search startup, Glean announced a $150 million Series F round on June 10. Led by Wellington Management, this round valued the company at $7.25 billion . Anysphere: The AI research lab behind the AI coding tool Cursor raised a substantial $900 million Series C round. Announced in June, this round led by Thrive Capital values Anysphere at nearly $10 billion . May Snorkel AI: Focused on AI data labeling, Snorkel AI secured a $100 million Series D round on May 29. The round, led by Addition, valued the company at $1.3 billion . LMArena: A community-driven benchmarking tool for AI models, LMArena raised a $100 million seed round on May 21. Co-led by Andreessen Horowitz and UC Investments, this early-stage funding valued the startup at $600 million . TensorWave: This Las Vegas-based AI infrastructure company announced a $100 million Series A round on May 14. Co-led by Magnetar Capital and AMD Ventures, this investment supports their infrastructure development. April SandboxAQ: Closing a $450 million Series E round on April 4, this company focused on AI models, particularly at the intersection with quantum technology, was valued at $5.7 billion . Investors included notable names like Nvidia and Google. Runway: Known for creating AI models for media production, Runway raised a $308 million Series D round announced on April 3. Led by General Atlantic, the round valued the company at $3 billion and included participation from SoftBank and Nvidia. March OpenAI: The AI behemoth raised a significant funding round valued at $40 billion , bringing the company’s valuation to $300 billion . This round, which closed on March 31, was led by SoftBank. Nexthop AI: An AI infrastructure company, Nexthop AI announced a $110 million Series A round on March 25, led by Lightspeed Venture Partners. Insilico Medicine: Based in Cambridge, MA, this company raised $110 million in a Series E round for its generative AI-powered drug discovery platform. Announced on March 13, the round valued the company at $1 billion . Celestial AI: Another AI infrastructure company, Celestial AI closed a $250 million Series C round on March 11. Led by Fidelity, this investment valued the company at $2.5 billion . Lila Sciences: Focused on creating a science superintelligence platform, Lila Sciences raised a substantial $200 million seed round led by Flagship Pioneering. The Cambridge, MA-based company received funding from several prominent firms. Reflection.Ai: This Brooklyn-based company, working on superintelligent autonomous systems, raised a $130 million Series A round. Led by Lightspeed Venture Partners and CRV, the round valued the 1-year-old company at $580 million . Turing: An AI coding startup that partners with LLM companies, Turing closed a $111 million Series E round on March 7. Led by Khazanah Nasional, the round valued Turing at $2.2 billion . Shield AI: An AI defense tech startup, Shield AI secured $240 million in a Series F round that closed on March 6. Co-led by L3Harris Technologies and Hanwha Aerospace, this round valued the company at $5.3 billion . Anthropic: A major AI research and large language model company, Anthropic announced a $3.5 billion Series E round on March 3. Led by Lightspeed, this significant raise valued the startup at a substantial $61.5 billion . February Together AI: This company, focused on open source generative AI and AI model development infrastructure, raised a $305 million Series B round on February 20. Co-led by Prosperity7 and General Catalyst, the round valued the company at $3.3 billion and included Nvidia among participants. Lambda: An AI infrastructure provider, Lambda announced a $480 million Series D round on February 19. Co-led by SGW and Andra Capital, the round valued the startup at nearly $2.5 billion and saw participation from Nvidia and ARK Invest. Abridge: An AI platform designed to transcribe patient-clinician conversations, Abridge was valued at $2.75 billion in a $250 million Series D round announced on February 17. The round was co-led by IVP and Elad Gil. Eudia: An AI legal tech company, Eudia raised $105 million in a Series A round led by General Catalyst. The round closed on February 13. EnCharge AI: An AI hardware startup, EnCharge AI closed a $100 million Series B round on February 13. Led by Tiger Global, the investment supports their hardware development. Harvey: Another AI legal tech company, Harvey secured a $300 million Series D round announced on February 12. Led by Sequoia, this raise valued the 3-year-old company at $3 billion and included participation from the OpenAI Startup Fund. January ElevenLabs: A synthetic voice startup, ElevenLabs raised a $180 million Series C round announced on January 30. Co-led by ICONIQ Growth and Andreessen Horowitz, the round valued the company at more than $3 billion . Hippocratic AI: This company develops large language models specifically for the healthcare industry. They announced a $141 million Series B round on January 9. Led by Kleiner Perkins, the round valued the company at more than $1.6 billion and saw participation from Andreessen Horowitz and Nvidia. What Fuels This Massive AI Investment? The significant inflow of Venture Capital into these US AI startups is driven by several factors: Market Demand: Businesses across almost every sector are eager to adopt AI solutions to improve efficiency, create new products, and gain a competitive edge. Technological Advancements: Breakthroughs in large language models, generative AI, and specialized AI hardware are creating new possibilities and viable commercial applications. Strategic Importance: AI is increasingly viewed as a critical technology for national security, economic growth, and global competitiveness, particularly in areas like defense and healthcare. Talent and Innovation Hubs: The US continues to be a major hub for AI research and talent, attracting top minds and fostering innovation that investors want to back. Scalability: Many AI technologies, once developed, offer high scalability, promising significant returns on investment if successfully deployed. Implications and Future Outlook for Artificial Intelligence This continued surge in AI funding suggests that the pace of development and deployment of Artificial Intelligence technologies will likely accelerate throughout 2025. While the list highlights significant investments, it also points to diverse applications of AI becoming commercially viable. The focus isn’t just on large language models but also on specialized AI for industries like healthcare, legal, and enterprise operations, as well as foundational infrastructure and hardware. For investors and those in related tech sectors, this landscape presents both opportunities and challenges. Understanding which areas are attracting the most significant AI investment can provide insights into future market trends and potential areas for growth or integration. As these US AI startups scale, their impact on various industries will become more pronounced. The first half of 2025 confirms that the AI investment boom is far from over. With 24 US AI startups already securing $100 million or more, the year is poised for continued growth and innovation in the field of Artificial Intelligence, fueled by substantial Venture Capital. To learn more about the latest AI market trends, explore our articles on key developments shaping AI features. This post US AI Startups Secure Astonishing $100M+ Funding Rounds in 2025 first appeared on BitcoinWorld and is written by Editorial Team
